|
KMID : 0383820090660010020
|
|
Tuberculosis and Respiratory Diseases
2009 Volume.66 No. 1 p.20 ~ p.26
|
|
|
Association between Bone Marrow Hypermetabolism on 18F-Fluorodeoxyglucose
|
|
Seol Hee-Yun
Kim Seong-Jang
Mok Jeong-Ha
Kim Ji-Eun
Kim Ki-Uk
Park Hye-Kyung
Kim Yun-Seong
Lee Min-Ki
Park Soon-Kew
Yoon Seong-Hoon
|
|
|
Abstract
|
|
|
Background: 18F-Fluorodeoxyglucose positron emission tomography (FDG-PET) is widely used for the diagnosis and staging of non-small cell lung cancer (NSCLC). The aim of this study is to determine whether the bone marrow hypermetabolism seen on FDG-PET predicts a response to chemotherapy in patients with NSCLC.
Methods: We evaluated the patients with advanced NSCLC and who were treated with combination chemotherapy. For determination of the standardized uptake value (SUV) of the bone marrow (BM SUV) on FDG-PET, regions of interest (ROIs) were manually drawn over the lumbar vertebrae (L1, 2, 3). ROIs were also drawn on a homogenous transaxial slice of the liver to obtain the bone marrow/ liver SUV ratio (BM/L SUV ratio). The response to chemotherapy was
evaluated according to the Response Evaluation Criteria in Solid Tumor (RECIST) criteria after three cycles of
chemotherapy.
Results: Fifty-nine NSCLC patients were included in the study. Multivariate analysis was performed using a logistic
regression model. The BM SUV and the BM/L SUV ratio on FDG-PET were not associated with a response to
chemotherapy in NSCLC patients (p=0.142 and 0.978, respectively).
Conclusion: The bone marrow hypermetabolism seen on FDG-PET can not predict a response to chemotherapy in NSCLC patients.
|
|
|
KEYWORD
|
|
|
Non-small cell lung cancer, Bone marrow, 18F-Fluorodeoxyglucose positron emission tomography
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|